Potential Sabotage of Host Cell Physiology by Apicomplexan Parasites for Their Survival Benefits

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Potential Sabotage of Host Cell Physiology by Apicomplexan Parasites for Their Survival Benefits

Plasmodium, Toxoplasma, Cryptosporidium, Babesia, and Theileria are the major apicomplexan parasites affecting humans or animals worldwide. These pathogens represent an excellent example of host manipulators who can overturn host signaling pathways for their survival. They infect different types of host cells and take charge of the host machinery to gain nutrients and prevent itself from host a...

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The intracellular stages of apicomplexan parasites are known to extensively modify their host cells to ensure their own survival. Recently, considerable progress has been made in understanding the molecular details of these parasite-dependent effects for Plasmodium-, Toxoplasma- and Theileria-infected cells. We have begun to understand how Plasmodium liver stage parasites protect their host hep...

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1 Institut Pasteur, Malaria Biology and Genetics Unit, Department of Parasitology and Mycology, Paris, France, 2 Institut Cochin, Laboratory Barriers and Pathogens, INSERM U-1016, CNRS UMR-8104, University of Paris Descartes, Paris, France, 3 Institute of Infection, Immunity and Inflammation, Wellcome Centre for Molecular Parasitology, Glasgow Biomedical Research Centre, University of Glasgow, ...

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Do apicomplexan parasites hijack the host cell microRNA pathway for their intracellular development?

RNA silencing plays an important role in development through the action of microRNAs, which fine tune the expression of a large portion of the genome. It is also very important in innate immune responses, especially in antiviral and antibacterial defenses in plants, insects, and animals. Two recent papers now indicate that apicomplexan parasites display the ability to interfere with host microR...

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ژورنال

عنوان ژورنال: Frontiers in Immunology

سال: 2017

ISSN: 1664-3224

DOI: 10.3389/fimmu.2017.01261